Which of the following is indicative of a medical condition?

The suffix "-osis" is commonly used in medical terminology to denote a condition, usually abnormal or diseased, involving a process or state. It can refer to an increase in the number or type of cells, a degenerative condition, or a pathological state. For instance, "sclerosis" refers to hardening of tissue, and "nephrosis" indicates a kidney disorder.

In contrast, the other suffixes hold different meanings and functions. "Meta-" is a prefix that indicates change or transformation and does not specifically pertain to a medical condition. The suffix "-oma" typically refers to tumors or neoplasms, which can often be pathological but is more focused specifically on growths rather than general conditions. The suffix "-ostomy" refers to the surgical creation of an opening, primarily used in the context of procedures, rather than indicating a disease state.

Thus, "-osis" is the correct choice because it directly signifies an abnormal condition affecting health, making it distinctly indicative of medical conditions.